Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage.

Abstract excerpt

Mutations in DJ-1 cause recessively transmitted early-onset Parkinson disease (PD), and oxidative damage to DJ-1 has been associated with the pathogenesis of late-onset sporadic PD. The precise biochemical function of DJ-1 remains elusive. Here, we report that DJ-1 is synthesized as a latent protease zymogen with low-intrinsic proteolytic activity. DJ-1 protease zymogen is activated by the removal of a 15-amino...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Enzyme Precursors
• Share to Mice, Knockout
• Share to Oncogene Proteins