Article
'Polymorphism-aided' Selective Targeting and Inhibition of Caspase-6 by a Novel Allosteric Inhibitor Towards Efficient Alzheimer's Disease Treatment.
Cell biochemistry and biophysics - 1 Sept 2020
Kumi Ransford Oduro, Agoni Clement, Issahaku Abdul Rashid, Olotu Fisayo A, Soliman Mahmoud E S
Abstract excerpt
The predominance of Alzheimer's disease (AD) among the aged remains a global challenge. As such, the search for alternative and effective therapeutic options continuous unabated. Among the therapeutic targets explored over the years toward impeding the progression of AD is caspase-6 (Casp6), although selectively targeting Casp6 remains a challenge due to high homology with other members of the caspase family....
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