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A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.

Human molecular genetics - 1 May 2015

Aharony Israel, Ehrnhoefer Dagmar E, Shruster Adi, Qiu Xiaofan, Franciosi Sonia, Hayden Michael R, Offen Daniel

Abstract excerpt

Over the past decade, increasing evidence has implied a significant connection between caspase-6 activity and the pathogenesis of Huntington's disease (HD). Consequently, inhibiting caspase-6 activity was suggested as a promising therapeutic strategy to reduce mutant Huntingtin toxicity, and to provide protection from mutant Huntingtin-induced motor and behavioral deficits. Here, we describe a novel caspase-6...

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Identifiers

PMID: 25616965
DOI: 10.1093/hmg/ddv023
PMCID: PMC4383866

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