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Article

Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.

Scientific reports - 13 Mar 2018

Tubeleviciute-Aydin Agne, Zhou Libin, Sharma Gyanesh, Soni Ishankumar V, Savinov Sergey N, Hardy Jeanne A, LeBlanc Andrea C

Abstract excerpt

The cysteine protease Caspase-6 (Casp6) is a potential therapeutic target of Alzheimer Disease (AD) and age-dependent cognitive impairment. To assess if Casp6 is essential to human health, we investigated the effect of CASP6 variants sequenced from healthy humans on Casp6 activity. Here, we report the effects of two rare Casp6 amino acid polymorphisms, R65W and G66R, on the catalytic function and structure of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29535332
DOI: 10.1038/s41598-018-22283-z
PMCID: PMC5849602

Genes

CASP6

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