Article
A three-stage genome-wide association study combining multilocus test and gene expression analysis for young-onset hypertension in Taiwan Han Chinese.
American journal of hypertension - 1 Jun 2014
Chiang Kuang-Mao, Yang Hsin-Chou, Liang Yu-Jen, Chen Jaw-Wen, Hwang Shiaw-Min, Ho Hung-Yun, Ting Chih-Tai, Lin Tsung-Hsien, Sheu Sheng-Hsiung, Tsai Wei-Chuan, Chen Jyh-Hong, Leu Hsin-Bang, Yin Wei-Hsian, Chiu Ting-Yu, Chen Chin-Iuan, Lin Shing-Jong, Thomas G Neil, Tomlinson Brian, Guo Youling, Gui Hong-Sheng, Sham Pak Chung, Lam Tai-Hing, Pan Wen-Harn
Abstract excerpt
BACKGROUND: Although many large-scale genome-wide association studies (GWASs) have been performed, only a few studies have successfully identified replicable, large-impact hypertension loci; even fewer studies have been done on Chinese subjects. Young-onset hypertension (YOH) is considered to be a more promising target disorder to investigate than late-onset hypertension because of its stronger genetic component....
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