Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study.

doi:10.1371/journal.pone.0032907

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Article

Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study.

PloS one - 1 Jan 2012

Yang Hsin-Chou, Liang Yu-Jen, Chen Jaw-Wen, Chiang Kuang-Mao, Chung Chia-Min, Ho Hung-Yun, Ting Chih-Tai, Lin Tsung-Hsien, Sheu Sheng-Hsiung, Tsai Wei-Chuan, Chen Jyh-Hong, Leu Hsin-Bang, Yin Wei-Hsian, Chiu Ting-Yu, Chern Ching-luan, Lin Shing-Jong, Tomlinson Brian, Guo Youling, Sham Pak C, Cherny Stacey S, Lam Tai Hing, Thomas G Neil, Pan Wen-Harn

Abstract excerpt

Hypertension is a complex disorder with high prevalence rates all over the world. We conducted the first genome-wide gene-based association scan for hypertension in a Han Chinese population. By analyzing genome-wide single-nucleotide-polymorphism data of 400 matched pairs of young-onset hypertensive patients and normotensive controls genotyped with the Illumina HumanHap550-Duo BeadChip, 100 susceptibility genes...

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Identifiers

PMID: 22479346
DOI: 10.1371/journal.pone.0032907
PMCID: PMC3315540

Genes

IGF1
SFMBT1
WWOX
GRB14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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