Article
Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese.
PloS one - 1 Jan 2014
Ma Ronald Ching Wan, Lee Heung Man, Lam Vincent Kwok Lim, Tam Claudia Ha Ting, Ho Janice Siu Ka, Zhao Hai-Lu, Guan Jing, Kong Alice Pik Shan, Lau Eric, Zhang Guozhi, Luk Andrea, Wang Ying, Tsui Stephen Kwok Wing, Chan Ting Fung, Hu Cheng, Jia Wei Ping, Park Kyong Soo, Lee Hong Kyu, Furuta Hiroto, Nanjo Kishio, Tai E Shyong, Ng Daniel Peng-Keat, Tang Nelson Leung Sang, Woo Jean, Leung Ping Chung, Xue Hong, Wong Jeffrey, Leung Po Sing, Lau Terrence C K, Tong Peter Chun Yip, Xu Gang, Ng Maggie Chor Yin, So Wing Yee, Chan Juliana Chung Ngor
Abstract excerpt
In Asia, young-onset type 2 diabetes (YOD) is characterized by obesity and increased risk for cardiovascular disease (CVD). In a genome-wide association study (GWAS) of 99 Chinese obese subjects with familial YOD diagnosed before 40-year-old and 101 controls, the T allele of rs1408888 in intron 1 of DACH1(Dachshund homolog 1) was associated with an odds ratio (OR) of 2.49(95% confidence intervals:1.57-3.96, P =...
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