Article
A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor.
The pharmacogenomics journal - 1 Dec 2010
Chung C-M, Wang R-Y, Chen J-W, Fann C S J, Leu H-B, Ho H-Y, Ting C-T, Lin T-H, Sheu S-H, Tsai W-C, Chen J-H, Jong Y-S, Lin S-J, Chen Y-T, Pan W-H
Abstract excerpt
Because angiotensin-converting enzyme (ACE) activity is implicated widely in biological systems, we aimed to identify its novel quantitative trait loci for the purposes of understanding ACE activity regulation and pharmacogenetics relating to ACE inhibitor (ACEI). We performed a two-stage genome-wide association study: (1) from 400 young-onset hypertension (YOH) subjects and (2) a confirmation study with an...
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