Article

Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness

2023-05-03

Abstract excerpt

Pluripotent stem cells are defined by their self-renewal capacity, which is the ability of the stem cells to proliferate indefinitely while maintaining the pluripotent identity essential for their ability to differentiate into any somatic cell lineage. However, understanding the mechanisms that control stem cell fitness versus the pluripotent cell identity is challenging. To investigate the interplay between these...

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Literature Corpus work: f7490e13-6d68-5ef8-b274-0e40a3d7822e
DOI: 10.1101/2023.05.03.539283

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