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Parallel genome-scale CRISPR-Cas9 screens uncouple human pluripotent stem cell identity versus fitness

17 Oct 2024

Abstract excerpt

Pluripotent stem cells have remarkable self-renewal capacity: the ability to proliferate indefinitely while maintaining the pluripotent identity essential for their ability to differentiate into almost any cell type in the body. To investigate the interplay between these two aspects of self-renewal, we perform four parallel genome-scale CRISPR-Cas9 loss-of-function screens interrogating stem cell fitness in hPSCs...

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PMID: 39419994
DOI: 10.1038/s41467-024-53284-4

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