Article
Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice.
American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2014
Scheving Lawrence A, Zhang Xiuqi, Garcia Oscar A, Wang Rebecca F, Stevenson Mary C, Threadgill David W, Russell William E
Abstract excerpt
Dsk5 mice have a gain of function in the epidermal growth factor receptor (EGFR), caused by a point mutation in the kinase domain. We analyzed the effect of this mutation on liver size, histology, and composition. We found that the livers of 12-wk-old male Dsk5 heterozygotes (+/Dsk5) were 62% heavier compared with those of wild-type controls (+/+). The livers of the +/Dsk5 mice compared with +/+ mice had larger...
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