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Article

Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2009

Dackor Jennifer, Li Manyu, Threadgill David W

Abstract excerpt

Epidermal growth factor receptor (EGFR) is a member of the ERBB family of receptor tyrosine kinases that has been shown to play an important developmental and physiologic role in many aspects of pregnancy. We have previously shown in mice that Egfr(tm1Mag) nullizygous placentas have fewer proliferative trophoblasts than wild-type and exhibit strain-specific defects in the spongiotrophoblast and labyrinth layers....

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Identifiers

PMID: 19466482
DOI: 10.1007/s00335-009-9189-2
PMCID: PMC8081568

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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