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Article

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

8 Jul 1997

Abstract excerpt

The signal transducer and activator of transcription, STAT5b, has been implicated in signal transduction pathways for a number of cytokines and growth factors, including growth hormone (GH). Pulsatile but not continuous GH exposure activates liver STAT5b by tyrosine phosphorylation, leading to dimerization, nuclear translocation, and transcriptional activation of the STAT, which is proposed to play a key role in...

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Share to Cytokine Signaling Pathways and Interactions
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PMID: 9207075
DOI: 10.1073/pnas.94.14.7239

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Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expressionPMID 9207075Read ↗

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Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone PulsesSemantic proximity Read ↗

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