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Article

Constitutively Active STAT5b Feminizes Mouse Liver Gene Expression

9 Apr 2022

Abstract excerpt

STAT5 is an essential transcriptional regulator of the sex-biased actions of GH in the liver. Delivery of constitutively active STAT5 (STAT5CA) to male mouse liver using an engineered adeno-associated virus with high tropism for the liver is shown to induce widespread feminization of the liver, with extensive induction of female-biased genes and repression of male-biased genes, largely mimicking results obtained...

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PMID: 35396838
DOI: 10.1210/endocr/bqac046

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Constitutively Active STAT5b Feminizes Mouse Liver Gene ExpressionPMID 35396838Read ↗

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