Article

Constitutively active STAT5b feminizes mouse liver gene expression

2022-02-14

Abstract excerpt

STAT5 is an essential transcriptional regulator of the sex-biased actions of growth hormone (GH) in the liver. Delivery of constitutively active STAT5 (STAT5 CA ) to male mouse liver using an engineered adeno-associated virus with high tropism for the liver is shown to induce widespread feminization of the liver, with extensive induction of female-biased genes and repression of male-biased genes, largely mimickin...

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Literature Corpus work: 6a67bf60-695b-5ffa-b3fc-e8732dbd196d
DOI: 10.1101/2022.02.14.480424

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