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Article

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.

The EMBO journal - 16 Nov 1998

Shima H, Pende M, Chen Y, Fumagalli S, Thomas G, Kozma S C

Abstract excerpt

Recent studies have shown that the p70(s6k)/p85(s6k) signaling pathway plays a critical role in cell growth by modulating the translation of a family of mRNAs termed 5'TOPs, which encode components of the protein synthetic apparatus. Here we demonstrate that homozygous disruption of the p70(s6k)/p85(s6k) gene does not affect viability or fertility of mice, but that it has a significant effect on animal growth,...

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Identifiers

PMID: 9822608
DOI: 10.1093/emboj/17.22.6649
PMCID: PMC1171010

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