Article
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.
The EMBO journal - 16 Nov 1998
Shima H, Pende M, Chen Y, Fumagalli S, Thomas G, Kozma S C
Abstract excerpt
Recent studies have shown that the p70(s6k)/p85(s6k) signaling pathway plays a critical role in cell growth by modulating the translation of a family of mRNAs termed 5'TOPs, which encode components of the protein synthetic apparatus. Here we demonstrate that homozygous disruption of the p70(s6k)/...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Embryo, Mammalian
- Embryonic and Fetal Development
- Fibroblasts
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Phenotype
- Phosphorylation
- Ribosomal Protein S6 Kinases
- Sequence Homology, Amino Acid