Article
The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice.
Hepatology (Baltimore, Md.) - 1 Oct 2013
Péan Noémie, Doignon Isabelle, Garcin Isabelle, Besnard Aurore, Julien Boris, Liu Bingkaï, Branchereau Sophie, Spraul Anne, Guettier Catherine, Humbert Lydie, Schoonjans Kristina, Rainteau Dominique, Tordjmann Thierry
Abstract excerpt
UNLABELLED: Many regulatory pathways are involved in liver regeneration after partial hepatectomy (PH) to initiate growth, protect liver cells, and sustain functions of the remnant liver. Bile acids (BAs), whose levels rise in the blood early after PH, stimulate both hepatocyte proliferation and protection, in part through their binding to the nuclear farnesoid X receptor (FXR). However, the effect of the BA...
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