Article
Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis.
Hepatology (Baltimore, Md.) - 1 Apr 2010
Blaas Leander, Kornfeld Jan-Wilhelm, Schramek Daniel, Musteanu Monica, Zollner Gernot, Gumhold Judith, van Zijl Franziska, Schneller Doris, Esterbauer Harald, Egger Gerda, Mair Markus, Kenner Lukas, Mikulits Wolfgang, Eferl Robert, Moriggl Richard, Penninger Josef, Trauner Michael, Casanova Emilio
Abstract excerpt
UNLABELLED: Growth hormone (GH) resistance and low serum levels of insulinlike growth factor 1 (IGF-1) are common features in human liver fibrosis and cirrhosis. Signal transducer and activator of transcription 5 (STAT5) controls several vital functions in the liver, including GH-mediated transcr...
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