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Article

Whole-genome sequencing of matched primary and metastatic hepatocellular carcinomas.

BMC medical genomics - 9 Jan 2014

Ouyang Limei, Lee Jeeyun, Park Cheol-Keun, Mao Mao, Shi Yujian, Gong Zhuolin, Zheng Hancheng, Li Yingrui, Zhao Yonggang, Wang Guangbiao, Fu Huiling, Kim Jhingook, Lim Ho Yeong

Abstract excerpt

BACKGROUND: To gain biological insights into lung metastases from hepatocellular carcinoma (HCC), we compared the whole-genome sequencing profiles of primary HCC and paired lung metastases. METHODS: We used whole-genome sequencing at 33X-43X coverage to profile somatic mutations in primary HCC (HBV+) and metachronous lung metastases (> 2 years interval). RESULTS: In total, 5,027-13,961 and 5,275-12,624 somatic...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24405831
DOI: 10.1186/1755-8794-7-2
PMCID: PMC3896667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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