Article
Mutational Landscape and Evolutionary Pattern of Liver and Brain Metastasis in Lung Adenocarcinoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Feb 2021
Jiang Tao, Fang Zhaoyuan, Tang Shijie, Cheng Ruirui, Li Yanan, Ren Shengxiang, Su Chunxia, Min Weijie, Guo Xianchao, Zhu Wei, Zhang Henghui, Hou Likun, Pan Yuanwei, Zhou Zhigang, Zhang Jun, Zhang Guojun, Yue Zhijian, Chen Luonan, Zhou Caicun
Abstract excerpt
INTRODUCTION: A comprehensive genomic analysis of paired primary tumors and their metastatic lesions may provide new insights into the biology of metastatic processes and therefore guide the development of novel strategies for intervention. To date, our knowledge of the genetic divergence and phylogenetic relationships among diverse metastatic lesions from cancer remains limited. METHODS: We performed whole-exome...
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