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Article

Genetic Heterogeneity Between Paired Primary and Brain Metastases in Lung Adenocarcinoma

1 Jan 2020

Abstract excerpt

PURPOSE: About one-third of nonsmall cell lung cancer (NSCLC) patients develop brain metastases (BM). However, there is an unmet need for early diagnosis and treatment of BM. The precise mechanism for BM is still unknown. However, the genetic heterogeneity between primary tumor and paired BM indicates that sampling from the primary tumor may not be able to fully represent the mutational status in metastases. In...

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PMID: 32922114
DOI: 10.1177/1179554920947335

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