Article
Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.
Cancer discovery - 1 Nov 2015
Brastianos Priscilla K, Carter Scott L, Santagata Sandro, Cahill Daniel P, Taylor-Weiner Amaro, Jones Robert T, Van Allen Eliezer M, Lawrence Michael S, Horowitz Peleg M, Cibulskis Kristian, Ligon Keith L, Tabernero Josep, Seoane Joan, Martinez-Saez Elena, Curry William T, Dunn Ian F, Paek Sun Ha, Park Sung-Hye, McKenna Aaron, Chevalier Aaron, Rosenberg Mara, Barker Frederick G, Gill Corey M, Van Hummelen Paul, Thorner Aaron R, Johnson Bruce E, Hoang Mai P, Choueiri Toni K, Signoretti Sabina, Sougnez Carrie, Rabin Michael S, Lin Nancy U, Winer Eric P, Stemmer-Rachamimov Anat, Meyerson Matthew, Garraway Levi, Gabriel Stacey, Lander Eric S, Beroukhim Rameen, Batchelor Tracy T, Baselga Jose, Louis David N, Getz Gad, Hahn William C
Abstract excerpt
UNLABELLED: Brain metastases are associated with a dismal prognosis. Whether brain metastases harbor distinct genetic alterations beyond those observed in primary tumors is unknown. We performed whole-exome sequencing of 86 matched brain metastases, primary tumors, and normal tissue. In all clonally related cancer samples, we observed branched evolution, where all metastatic and primary sites shared a common...
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