Article
Whole genome sequencing of matched tumor, adjacent non-tumor tissues and corresponding normal blood samples of hepatocellular carcinoma patients revealed dynamic changes of the mutations profiles during hepatocarcinogenesis.
Oncotarget - 18 Apr 2017
Mao Ruifang, Liu Jie, Liu Guanfeng, Jin Shanshan, Xue Qingzhong, Ma Liang, Fu Yan, Zhao Na, Xing Jinliang, Li Lanjuan, Qiu Yunqing, Lin Biaoyang
Abstract excerpt
Hepatocellular carcinoma (HCC) has become the third most deadly disease worldwide and HBV is the major factor in Asia and Africa. We conducted 9 WGS (whole genome sequencing) analyses for matched samples of tumor, adjacent non-tumor tissues and normal blood samples of HCC patients from three HBV positive patients. We then validated the mutations identified in a larger cohort of 177 HCC patients. We found that the...
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