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Genetics of chloroquine-resistant malaria: a haplotypic view

6 Dec 2013

Abstract excerpt

The development and rapid spread of chloroquine resistance (CQR) in Plasmodium falciparum have triggered the identification of several genetic target(s) in the P. falciparum genome. In particular, mutations in the Pfcrt gene, specifically, K76T and mutations in three other amino acids in the region adjoining K76 (residues 72, 74, 75 and 76), are considered to be highly related to CQR. These various mutations form...

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PMID: 24402147
DOI: 10.1590/0074-0276130274

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