Article
Large-scale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt.
Malaria journal - 28 Mar 2012
Takahashi Nobuyuki, Tanabe Kazuyuki, Tsukahara Takahiro, Dzodzomenyo Mawuli, Dysoley Lek, Khamlome Boualam, Sattabongkot Jetsumon, Nakamura Masatoshi, Sakurai Miki, Kobayashi Jun, Kaneko Akira, Endo Hiroyoshi, Hombhanje Francis, Tsuboi Takafumi, Mita Toshihiro
Abstract excerpt
BACKGROUND: In Plasmodium falciparum, resistance to chloroquine (CQ) is conferred by a K to T mutation at amino acid position 76 (K76T) in the P. falciparum CQ transporter (PfCRT). To date, at least 15 pfcrt genotypes, which are represented by combinations of five amino acids at positions 72-76, have been described in field isolates from various endemic regions. To identify novel mutant pfcrt genotypes and to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.