Article
Molecular analysis of chloroquine resistance in Plasmodium falciparum in Yunnan Province, China.
Tropical medicine & international health : TM & IH - 1 Sept 2007
Yang Zhaoqing, Zhang Zaixin, Sun Xiaodong, Wan Wenlin, Cui Long, Zhang Xiang, Zhong Daibin, Yan Guiyun, Cui Liwang
Abstract excerpt
Resistance of Plasmodium falciparum to chloroquine (CQ) is determined by the mutation at K76T of the P. falciparum chloroquine resistance transporter (pfcrt) gene and modified by other mutations in this gene and in the P. falciparum multidrug resistance 1 (pfmdr1) gene. To determine the extent of polymorphisms in these genes in field P. falciparum isolates from Yunnan province of China, we genotyped the pfcrt...
Topics
- Animals
- Antimalarials
- China
- Chloroquine
- Drug Resistance, Multiple
- Genes, MDR
- Genotype
- Humans
- Membrane Transport Proteins
- Mutation
- Plasmodium falciparum