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Article

A Molecular Marker for Chloroquine-Resistant Falciparum Malaria

25 Jan 2001

Abstract excerpt

BACKGROUND: Chloroquine-resistant Plasmodium falciparum malaria is a major health problem, particularly in sub-Saharan Africa. Chloroquine resistance has been associated in vitro with point mutations in two genes, pfcrt and pfmdr 1, which encode the P. falciparum digestive-vacuole transmembrane proteins PfCRT and Pgh1, respectively. METHODS: To assess the value of these mutations as markers for clinical...

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PMID: 11172152
DOI: 10.1056/nejm200101253440403

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