Article
Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates.
Malaria journal - 5 Jun 2020
Foguim Francis Tsombeng, Bogreau Hervé, Gendrot Mathieu, Mosnier Joel, Fonta Isabelle, Benoit Nicolas, Amalvict Rémy, Madamet Marylin, Wein Sharon, Pradines Bruno
Abstract excerpt
BACKGROUND: The Plasmodium falciparum chloroquine transporter gene (pfcrt) is known to be involved in chloroquine and amodiaquine resistance, and more particularly the mutations on the loci 72 to 76 localized within the second exon. Additionally, new mutations (T93S, H97Y, C101F, F145I, M343L, C350R and G353V) were recently shown to be associated with in vitro reduced susceptibility to piperaquine in Asian or...
Topics
- Africa
- Antimalarials
- Drug Resistance
- France
- Humans
- Membrane Transport Proteins
- Mutation
- Plasmodium falciparum
- Protozoan Proteins
- Quinolines
- Travel