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Article

Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2010

Li Ming D, Xu Qing, Lou Xiang-Yang, Payne Thomas J, Niu Tianhua, Ma Jennie Z

Abstract excerpt

Several previous genome-wide and targeted association studies revealed that variants in the CHRNA5-CHRNA3-CHRNB4 (CHRNA5/A3/B4) gene cluster on chromosome 15 that encode the alpha5, alpha3, and beta4 subunits of the nicotinic acetylcholine receptors (nAChRs) are associated with nicotine dependence (ND) in European Americans (EAs) or others of European origin. Considering the distinct linkage disequilibrium...

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Source

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Identifiers

PMID: 19859904
DOI: 10.1002/ajmg.b.31043
PMCID: PMC2924635

Genes

CHRNA3
CHRNA5
CHRNB4

Provenance

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