Article
Mutations in the embB gene and their association with ethambutol resistance in multidrug-resistant Mycobacterium tuberculosis clinical isolates from Poland.
BioMed research international - 1 Jan 2013
Bakuła Zofia, Napiórkowska Agnieszka, Bielecki Jacek, Augustynowicz-Kopeć Ewa, Zwolska Zofia, Jagielski Tomasz
Abstract excerpt
Ethambutol (EMB) continues to be used as part of a standard drug regimen for the treatment of tuberculosis (TB). Mutations in the embB gene and those within its conserved EMB resistance determining region (ERDR) in particular have repeatedly been associated with resistance to EMB in Mycobacterium tuberculosis. The aim of this study was to examine the mutational "hot spots" in the embB gene, including the ERDR,...
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