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Article

Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Nov 2004

Lee Ann S G, Othman Siti Noor Khadijah, Ho Yu Min, Wong Sin Yew

Abstract excerpt

Genetic analysis of the embB gene revealed mutations in 17 (68%) of 25 ethambutol (EMB) resistant isolates (M306I, M306V, M306L, Q497R) but also in 4 (20%) of 20 EMB-susceptible isolates of Mycobacterium tuberculosis, namely, an ATG-->ATM substitution resulting in M306I, G406N, and the novel alterations M423I and A659T.

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Source

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Identifiers

PMID: 15504879
DOI: 10.1128/AAC.48.11.4447-4449.2004
PMCID: PMC525425

Genes

EMB
ATM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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