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Article

Using Evolution to Guide Protein Engineering: The Devil IS in the Details.

Biophysical journal - 12 Jul 2016

Swint-Kruse Liskin

Abstract excerpt

For decades, protein engineers have endeavored to reengineer existing proteins for novel applications. Overall, protein folds and gross functions can be readily transferred from one protein to another by transplanting large blocks of sequence (i.e., domain recombination). However, predictably fine-tuning function (e.g., by adjusting ligand affinity, specificity, catalysis, and/or allosteric regulation) remains a...

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Identifiers

PMID: 27410729
DOI: 10.1016/j.bpj.2016.05.030
PMCID: PMC4945580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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