Article
Identification of biochemically neutral positions in liver pyruvate kinase.
Proteins - 1 Oct 2020
Martin Tyler A, Wu Tiffany, Tang Qingling, Dougherty Larissa L, Parente Daniel J, Swint-Kruse Liskin, Fenton Aron W
Abstract excerpt
Understanding how each residue position contributes to protein function has been a long-standing goal in protein science. Substitution studies have historically focused on conserved protein positions. However, substitutions of nonconserved positions can also modify function. Indeed, we recently identified nonconserved positions that have large substitution effects in human liver pyruvate kinase (hLPYK), including...
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