Article
Rheostat functional outcomes occur when substitutions are introduced at nonconserved positions that diverge with speciation.
Protein science : a publication of the Protein Society - 1 Sept 2021
Swint-Kruse Liskin, Martin Tyler A, Page Braelyn M, Wu Tiffany, Gerhart Paige M, Dougherty Larissa L, Tang Qingling, Parente Daniel J, Mosier Brian R, Bantis Leonidas E, Fenton Aron W
Abstract excerpt
When amino acids vary during evolution, the outcome can be functionally neutral or biologically-important. We previously found that substituting a subset of nonconserved positions, "rheostat" positions, can have surprising effects on protein function. Since changes at rheostat positions can facilitate functional evolution or cause disease, more examples are needed to understand their unique biophysical...
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