Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme.

Abstract excerpt

Optimization processes, such as evolution, are constrained by diminishing returns-the closer the optimum, the smaller the benefit per mutation, and by tradeoffs-improvement of one property at the cost of others. However, the magnitude and molecular basis of these parameters, and their effect on evolutionary transitions, remain unknown. Here we pursue a complete functional transition of an enzyme with a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Enzymes
• Share to Carboxylic Ester Hydrolases