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Article

GroEL/ES buffering and compensatory mutations promote protein evolution by stabilizing folding intermediates.

Journal of molecular biology - 23 Sept 2013

Wyganowski Kirsten T, Kaltenbach Miriam, Tokuriki Nobuhiko

Abstract excerpt

Maintaining stability is a major constraint in protein evolution because most mutations are destabilizing. Buffering and/or compensatory mechanisms that counteract this progressive destabilization during functional adaptation are pivotal for protein evolution as well as protein engineering. However, the interplay of these two mechanisms during a full evolutionary trajectory has never been explored. Here, we...

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Identifiers

PMID: 23810906
DOI: 10.1016/j.jmb.2013.06.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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