Article
Quantifying missing heritability at known GWAS loci.
PLoS genetics - 1 Jan 2013
Gusev Alexander, Bhatia Gaurav, Zaitlen Noah, Vilhjalmsson Bjarni J, Diogo Dorothée, Stahl Eli A, Gregersen Peter K, Worthington Jane, Klareskog Lars, Raychaudhuri Soumya, Plenge Robert M, Pasaniuc Bogdan, Price Alkes L
Abstract excerpt
Recent work has shown that much of the missing heritability of complex traits can be resolved by estimates of heritability explained by all genotyped SNPs. However, it is currently unknown how much heritability is missing due to poor tagging or additional causal variants at known GWAS loci. Here, we use variance components to quantify the heritability explained by all SNPs at known GWAS loci in nine diseases from...
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