Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data.

Human molecular genetics - 1 Sept 2014

Chen Guo-Bo, Lee Sang Hong, Brion Marie-Jo A, Montgomery Grant W, Wray Naomi R, Radford-Smith Graham L, Visscher Peter M

Abstract excerpt

As custom arrays are cheaper than generic GWAS arrays, larger sample size is achievable for gene discovery. Custom arrays can tag more variants through denser genotyping of SNPs at associated loci, but at the cost of losing genome-wide coverage. Balancing this trade-off is important for maximizing experimental designs. We quantified both the gain in captured SNP-heritability at known candidate regions and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human
Share to Colitis, Ulcerative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crohn Disease

Share to Genome-Wide Association Study

Share to Inflammatory Bowel Diseases

Share to Inheritance Patterns

Share to Oligonucleotide Array Sequence Analysis

Share to Sample Size

Source

Open in PubMed Open full text

Identifiers

PMID: 24728037
DOI: 10.1093/hmg/ddu174
PMCID: PMC4119411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data.PMID 24728037Read ↗

Performance of risk prediction for inflammatory bowel disease based on genotyping platform and genomic risk score method.Semantic proximity Read ↗

Quantifying missing heritability at known GWAS loci.Semantic proximity Read ↗

Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease.Semantic proximity Read ↗

Resolving inflammatory bowel disease risk variants to genes and cell typesSemantic proximity Read ↗

Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping.Semantic proximity Read ↗

Narrow-sense heritability estimation of complex traits using identity-by-descent information.Semantic proximity Read ↗

Leveraging correlations between variants in polygenic risk scores to detect heterogeneity in GWAS cohorts.Semantic proximity Read ↗

Fine-mapping inflammatory bowel disease loci to single-variant resolution.Semantic proximity Read ↗

Heritability in inflammatory bowel disease: from the first twin study to genome-wide association studies.Semantic proximity Read ↗

Improved risk prediction for Crohn's disease with a multi-locus approach.Semantic proximity Read ↗

Evidence for an inflammatory bowel disease locus on chromosome 3p26: linkage, transmission/disequilibrium and partitioning of linkage.Semantic proximity Read ↗

Estimation of effect size distribution from genome-wide association studies and implications for future discoveries.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.