Different impacts of TP53 mutations on cell cycle-related gene expression among cancer types.

Abstract excerpt

Functional properties caused by TP53 mutations are involved in cancer development and progression. Although most of the mutations lose normal p53 functions, some of them, gain-of-function (GOF) mutations, exhibiting novel oncogenic functions. No reports have analyzed the impact of TP53 mutations on the gene expression profile of the p53 signaling pathway across cancer types. This study is a cross-cancer type...

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• Cancer Genomics and Diagnostics
• Cancer-related Molecular Pathways
• Cell Cycle
• Epigenetics and DNA Methylation
• Gene Expression