Article
p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes.
Molecular cancer research : MCR - 1 Aug 2017
Pappas Kyrie, Xu Jia, Zairis Sakellarios, Resnick-Silverman Lois, Abate Francesco, Steinbach Nicole, Ozturk Sait, Saal Lao H, Su Tao, Cheung Pamela, Schmidt Hank, Aaronson Stuart, Hibshoosh Hanina, Manfredi James, Rabadan Raul, Parsons Ramon
Abstract excerpt
TP53 is the most commonly mutated tumor suppressor gene and its mutation drives tumorigenesis. Using ChIP-seq for p53 in the absence of acute cell stress, we found that wild-type but not mutant p53 binds and activates numerous tumor suppressor genes, including PTEN, STK11(LKB1), miR-34a, KDM6A(UTX), FOXO1, PHLDA3, and TNFRSF10B through consensus binding sites in enhancers and promoters. Depletion of p53 reduced...
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