Article
Recent advances in p53 research: an interdisciplinary perspective.
Cancer gene therapy - 1 Jan 2009
Olivier M, Petitjean A, Marcel V, Pétré A, Mounawar M, Plymoth A, de Fromentel C C, Hainaut P
Abstract excerpt
The TP53 gene is one of the most studied genes in human cancer. In recent years, considerable interest was focused on mutant p53, the abnormal protein product of TP53 somatic or germline alleles with missense mutations that often accumulate in cancer cells. There is now compelling experimental evidence that many mutations can exert mutant-specific, gain-of-function effects by perturbing the regulation of...
Topics
- Alleles
- Animals
- Biomedical Research
- Gene Expression Regulation, Neoplastic
- Humans
- Mice
- Mutation, Missense
- Neoplasms
- Tumor Suppressor Protein p53