TP53 mutations, expression and interaction networks in human cancers.

Abstract excerpt

Although the associations of p53 dysfunction, p53 interaction networks and oncogenesis have been widely explored, a systematic analysis of TP53 mutations and its related interaction networks in various types of human cancers is lacking. Our study explored the associations of TP53 mutations, gene expression, clinical outcomes, and TP53 interaction networks across 33 cancer types using data from The Cancer Genome...

Topics

• Cell Line, Tumor
• Computational Biology
• Databases, Nucleic Acid
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Gene Regulatory Networks
• Genetic Association Studies
• Genotype
• Humans
• Kaplan-Meier Estimate
• Mutation