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Article

TP53 mutations in cancer: Molecular features and therapeutic opportunities (Review).

International journal of molecular medicine - 1 Jan 2025

Tornesello Maria Lina

Abstract excerpt

The tumour suppressor factor p53 plays an essential role in regulating numerous cellular processes, including the cell cycle, DNA repair, apoptosis, autophagy, cell metabolism and immune response. TP53 is the most commonly mutated gene in human cancers. These mutations are primarily non‑synonymous changes that produce mutant p53 proteins characterized by loss of function, a dominant negative effect on p53...

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Identifiers

PMID: 39450536
DOI: 10.3892/ijmm.2024.5448
PMCID: PMC11554381

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