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Article

Molecular architecture of a multifunctional MCM complex.

Nucleic acids research - 1 Feb 2012

Sanchez-Berrondo June, Mesa Pablo, Ibarra Arkaitz, Martínez-Jiménez Maria I, Blanco Luis, Méndez Juan, Boskovic Jasminka, Montoya Guillermo

Abstract excerpt

DNA replication is strictly regulated through a sequence of steps that involve many macromolecular protein complexes. One of them is the replicative helicase, which is required for initiation and elongation phases. A MCM helicase found as a prophage in the genome of Bacillus cereus is fused with a primase domain constituting an integrative arrangement of two essential activities for replication. We have isolated...

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Identifiers

PMID: 21984415
DOI: 10.1093/nar/gkr831
PMCID: PMC3273815

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