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Article

Unwinding of a DNA replication fork by a hexameric viral helicase.

Nature communications - 20 Sept 2021

Javed Abid, Major Balazs, Stead Jonathan A, Sanders Cyril M, Orlova Elena V

Abstract excerpt

Hexameric helicases are motor proteins that unwind double-stranded DNA (dsDNA) during DNA replication but how they are optimised for strand separation is unclear. Here we present the cryo-EM structure of the full-length E1 helicase from papillomavirus, revealing all arms of a bound DNA replication fork and their interactions with the helicase. The replication fork junction is located at the entrance to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34545080
DOI: 10.1038/s41467-021-25843-6
PMCID: PMC8452682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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