Article
Polymorphism in the alpha cardiac muscle actin 1 gene is associated to susceptibility to chronic inflammatory cardiomyopathy.
PloS one - 1 Jan 2013
Frade Amanda Farage, Teixeira Priscila Camilo, Ianni Barbara Maria, Pissetti Cristina Wide, Saba Bruno, Wang Lin Hui Tzu, Kuramoto Andréia, Nogueira Luciana Gabriel, Buck Paula, Dias Fabrício, Giniaux Helene, Llored Agnes, Alves Sthefanny, Schmidt Andre, Donadi Eduardo, Marin-Neto José Antonio, Hirata Mario, Sampaio Marcelo, Fragata Abílio, Bocchi Edimar Alcides, Stolf Antonio Noedir, Fiorelli Alfredo Inacio, Santos Ronaldo Honorato Barros, Rodrigues Virmondes, Pereira Alexandre Costa, Kalil Jorge, Cunha-Neto Edecio, Chevillard Christophe
Abstract excerpt
AIMS: Chagas disease, caused by the protozoan Trypanosoma cruzi is endemic in Latin America, and may lead to a life-threatening inflammatory dilated, chronic Chagas cardiomyopathy (CCC). One third of T. cruzi-infected individuals progress to CCC while the others remain asymptomatic (ASY). A possible genetic component to disease progression was suggested by familial aggregation of cases and the association of...
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