Article

Mitochondrial DNA Haplogroups and Variants Predispose to Chagas Disease Cardiomyopathy

2023-10-13

Abstract excerpt

Cardiomyopathies are major causes of heart failure. Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central, South America. Thirty percent of the cases evolve into chronic cardiomyopathy (CCC) with worse prognosis as compared with other cardiomyopathies. In vivo bioenergetic analysis and ex vivo proteomic analysis of myocardial tissues highlighted worse mitochondrial dysfuncti...

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Literature Corpus work: e864ebf7-4af3-5141-ba1d-2b208d47095c
DOI: 10.20944/preprints202310.0829.v1

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