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Article

Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014

Mainardi Sara, Mijimolle Nieves, Francoz Sarah, Vicente-Dueñas Carolina, Sánchez-García Isidro, Barbacid Mariano

Abstract excerpt

Ubiquitous expression of a resident K-Ras(G12V) oncogene in adult mice revealed that most tissues are resistant to K-Ras oncogenic signals. Indeed, K-Ras(G12V) expression only induced overt tumors in lungs. To identify these transformation-permissive cells, we induced K-Ras(G12V) expression in a very limited number of adult lung cells (0.2%) and monitored their fate by X-Gal staining, a surrogate marker...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24367082
DOI: 10.1073/pnas.1320383110
PMCID: PMC3890787

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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