Article
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.
Cancer cell - 1 Apr 2004
Tuveson David A, Shaw Alice T, Willis Nicholas A, Silver Daniel P, Jackson Erica L, Chang Sandy, Mercer Kim L, Grochow Rebecca, Hock Hanno, Crowley Denise, Hingorani Sunil R, Zaks Tal, King Catrina, Jacobetz Michael A, Wang Lifu, Bronson Roderick T, Orkin Stuart H, DePinho Ronald A, Jacks Tyler
Abstract excerpt
Activating mutations in the ras oncogene are not considered sufficient to induce abnormal cellular proliferation in the absence of cooperating oncogenes. We demonstrate that the conditional expression of an endogenous K-ras(G12D) allele in murine embryonic fibroblasts causes enhanced proliferation and partial transformation in the absence of further genetic abnormalities. Interestingly, K-ras(G12D)-expressing...
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