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Article

Alveolar type II cells possess the capability of initiating lung tumor development.

PloS one - 1 Jan 2012

Lin Chuwen, Song Hai, Huang Cecilia, Yao Erica, Gacayan Rhodora, Xu Shan-Mei, Chuang Pao-Tien

Abstract excerpt

Identifying cells of tumor origin is a fundamental question in tumor biology. Answers to this central question will not only advance our understanding of tumor initiation and progression but also have important therapeutic implications. In this study, we aimed to uncover the cells of origin of lung adenocarcinoma, a major subtype of non-small cell lung cancer. To this end, we developed new mouse models of lung...

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Share to Adenocarcinoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Genes, ras

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Source

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Identifiers

PMID: 23285300
DOI: 10.1371/journal.pone.0053817
PMCID: PMC3527621

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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